Description

M105 2-(2′-Nitrophenylsulfenyl)-3-methyl-3-bromoinolenine

[ 27933-36-4 ] f.w.: 363.2 daltons

Overview

BNPS Skatole is a mild oxidant and brominating reagent that cleaves proteins on the C-terminal side of tryptophan residues. BNPS Skatole is soluble in acetone or chloroform, yielding a clear bright yellow solution.
BNPS Skatole has been used to cleave peptide bonds after amino acids with available C?-C? double bonds, as in tryptophan. The resulting C-terminal lactones can be attached to amino containing compounds or supports.

Description

Cleaves tryptophan residues. The amino acid sequence of cytotoxin mitogillan was determined with peptide fragments produced by BNPS SKATOLE> Purity ca. 90%.

Reference

1. Hunziker, P.E., et al. (1980) Biochem. J. 187, 515-519.
2. Fernandez-Lunn, T.L., et al. (1985) Biochem. 24, 861-867.

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