Description

M120  (2S)-2-Amino-1,4-dimercaptobutane hydrochloride

f.w.: 173.73 daltons

Overview

DTBA is simply the best reducing agent for reducing disulfide bonds. Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues. DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value. DTBA reduces disulfide bonds faster than DTT, especially in neutral aqueous systems. The amino group of DTBA enables its isolation by cation exchange and facilitates its conjugation. DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions. Dibutylthioamine has very desirable physicochemical attributes. The HCl salt of DTBA is nearly odorless with a high solubility in water.

Description

syn.  (2S)-2-Amino-1,4-dimercaptobutane hydrochloride; (S)-2-Aminobutane-1,4-dithiol hydrochloride; DTBA; DTBA-HCl

Reference

1. JACS 134, 4057-4059 (2012).

Bulletlist

DTBA is simply the best reducing agent for reducing disulfide bonds

DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value

DTBA reduces disulfide bonds faster than DTT, especially in neutral aqueous systems

The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation

DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions

Dibutylthioamine has very desirable physicochemical attributes

The HCl salt of DTBA is nearly odorless with a high solubility in water

Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues

Kinetics rather than thermodynamics controls the reduction